HPE ProLiant DL380 Gen10 server

HPE ProLiant DL380 Gen10 server

Intel Xeon-Gold 6250 (3.9GHz/8-core/185W)
Special Price $7,919.99 Regular Price $11,699.00

HPE ProLiant DL380 Gen10 server

MFG.PART: P24850-B21

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Special Price $7,919.99 Regular Price $11,699.00
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The HPE ProLiant DL380 Gen10 server delivers the latest in security, performance and expandability, backed by a comprehensive warranty. Standardize on the industry's most trusted compute platform. The HPE ProLiant DL380 Gen10 server is securely designed to reduce costs and complexity, featuring the First and Second Generation Intel® Xeon® Processor Scalable Family with up to a 60% performance gain and 27% increase in cores, plus the HPE 2933 MT/s DDR4 SmartMemory supporting 1.5 TB. 



Defend Applications and Data Before Your Server is Built with HPE Trusted Supply Chain

A new first line of defense against cyber-attackers with select servers built to the world’s toughest security standards in secured facilities, bringing together security, processes and people to deliver protection for your most sensitive applications and data even before your server is built.

Built in secure HPE facilities to the most stringent Country of Origin USA and conformance requirements, HPE Trusted Supply Chain servers are inspected to be free from malicious microcode and counterfeit parts, safeguarding it against cyber-exploits throughout its life cycle.

With hardened security built in, HPE Trusted Supply Chain hardens the protections designed into select HPE products with unrivaled supply chain visibility and standards compliance providing a 360-degree view and mitigation plan for current and emerging cyber-threats.

World-Class Performance featuring Enhanced Compute Density

The ProLiant DL380 now features significantly enhanced GPU density, expanding support from five to seven Full-Height, Half-Length, Single-Width Accelerators/GPUs; or up to six in a balanced configuration with additional PCIe expansion via the tertiary riser.

Leveraging HPE's most popular 2U rackmount server, fitting standard depth racks, customers can benefit from one of the densest Accelerator/GPU platforms with an extensive set of Accelerator options, enabling diverse cloud workload performance and optimization of AI and deep learning experiences.


Flexible Design Making Your Investment Expand As Your Business Needs Grow

The HPE ProLiant DL380 Gen10 server has an adaptable chassis, including new Hewlett Packard Enterprise modular drive bay configuration options with up to 30 SFF, up to 19 LFF or up to 20 NVMe drive options along with support for up to three double wide GPU options.

Adapting and growing to changing business needs, Networking Choice (NC) server models provide flexibility in the primary networking choice while
Embedded LOM server models offer an embedded 4x1GbE by default; both provide network options (1GbE to 100GbE) via HPE FlexibleLOM or PCIe
standup adapters.

HPE Persistent Memory works with DRAM to provide fast, high capacity, cost effective memory and storage to transform big data workloads and analytics by enabling data to be stored, moved, and processed quickly.

Industry Leading Services and Ease of Deployment

The HPE ProLiant DL380 Gen10 server comes with a complete set of HPE Technology Services, delivering confidence, reducing risk, and helping customers realize agility and stability.

HPE Pointnext Services simplifies all stages of the IT journey. Advisory and Transformation Services professionals understand customer challenges and design an optimal solution. Professional Services enable rapid deployment of solutions and Operational Services provide ongoing support.

Tech Specs

Tech specs


Processor Type Intel
Processor Name Xeon Gold
Processor cores 8-cores
Processor Number 6250
Processor Max Turbo Speed 4.5 GHZ
Processor Installed 1


Memory, Standard 32 GB (1x32GB) 
Max Memory Supported 1.5TB
Memory Slots 23 DIMM slots
Memory Type HPE 32GB (1x32GB) Dual Rank x4 DDR4-2933 CAS-21-21-21 Registered Smart Memory Kit

Power Features

Power Device Type Power supply - hot-plug
50/60 hertz
Power Provided
800 watt
Power Supplies Installed
Power Supplies Supported
Redundant Power Supply

Expansion Slots

Expansion Slots 8, for detailed descriptions reference the QuickSpecs

Network Controller

Network Controller HPE 1 Gb 331i Ethernet adapter 4-ports per controller and/or optional HPE FlexibleLOM, depending on model

Storage Controller

Storage Controller 1 HPE Smart Array S100i and/or 1 HPE Smart Array P408i-a and/or 1 HPE Smart Array P816i-a and/or 1 HPE Smart Array E208i-a, depending on the model


Dimensions (metric) 44.55 x 73.03 x 8.74 cm
Weight 14.76 kg (32.54lbs)
Form Factor
Form Factor 2U

Power Supply

Power Provided 800 watt
Power Device Type Power supply - hot-plug
Frequency 50/60 hertz
Power Supplies Installed 1
Power Supplies Supported 2


Awards & Reviews

Awards & Reviews

In my experience with HPE, and in general, their servers work out of the box. They’ve been very reliable. So far we’ve seen that from these ML110s. We haven’t had any issues and the performance has been great.”

Jerard Reibel, information systems and information technology manager, LTP

Solutions & Services

Solutions & Services


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